Description of changes in the cytokine profile of patients with progression of chronic obstructive pulmonary disease. Determination of types of T-helper response, characteristic for pathology. Improving the diagnosis and treatment of patients with COPD.
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Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment Vladivostok Branch The changes in the profile of cytokines in progressing chronic obstructive pulmonary disease PhD in Biology Vitkina T.I. PhD in Biology Denisenko Yu.K. Master’s Degree student Davydova K.A. Abstract The aim of this study was to describe changes in cytokine profile in patients with progressing chronic obstructive pulmonary disease (COPD). The profile of circulating cytokines (IL-4, IL-6, IL-10, IL-17A, IL-21, TNF-?, IFN-?, TFG-?1) was determined and analyzed in patients with progressing COPD of varying severity in remission. These data were used to reveal types of T-helper response, which are typical for this pathology. The results can be used to improve the diagnosis and treatment of patients with COPD. Keywords: COPD, T-helpers, cytokines. Аннотация Цель данного исследования - описание изменений цитокинового профиля пациентов по мере прогрессирования хронической обструктивной болезни легких (ХОБЛ). All participants have given a voluntary informed consent. Serum levels of TNF-? (tumor necrosis factors ?), IL-4 (interleukin 4), IL-6, IL-10, IL-17А, IFN-? (interferon ?) were determined by using multiplex quantitative flow cytometry (test-system Cytometric Bead Array BD, USA). Serum levels of TFG-?1 (transforming growth factor ?1) and IL-21 were determined by using ELISA (enzyme-linked immunosorbent assay) (Genzyme diagnostics, USA). Data were described as median values with interquartile range. Differences between groups were evaluated by using the Mann-Whitney U-test. Differences was considered significant at p-value
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