The process of reducing dissimilation sulfate and the accumulation of hydrogen sulphide, role in inflammatory bowel diseases, including ulcerative colitis. The characteristics of these bacteria and their mechanism for reducing dissimilation sulfate.
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Dissimilatory sulfate reduction in the intestinal sulfate-reducing bacteria Sulfate-reducing bacteria (SRB) are common in anaerobic areas of soils, wetlands, fresh and marine waters, and available in the microbiocenosis of large intestine of humans and animals [1,63]. These microorganisms, dissimilating sulfate to hydrogen sulfide, are involved in the process of biogeochemical sulfur cycle in nature [63]. The sulfate dissimilation process is called the „dissimilatory sulfate reduction” or „sulfate respiration” [54]. Intensive sulfate reduction by SRB, and accordingly the accumulation of toxic hydrogen sulfide in the intestine, is leading to the development of various diseases [12, 16, 46, 49, 55]. SRB and the products of their metabolism are often found during bloody diarrhea and abdominal pain [51, 55]. It is believed that they can cause weight loss, frequent defecation, arthritis, rheumatic diseases, increased intestinal permeability, ulcerative colitis, and malaise, in general [12, 13, 15, 17, 46, 49, 55].
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