Применение традиционных нейролептиков в период ремиссии у больных шизофренией с избытком массы тела, вызванным атипичными антипсихотическими препаратами - Статья
Анализ результатов обследования больных с приступообразной шизофренией в периоде терапевтической ремиссии. Оценка целесообразности перевода больных шизофренией в период ремиссии на терапию традиционными нейролептиками в случае избыточной массы тела.
Аннотация к работе
Prescription of traditional neuroleptics in the remission period for schizophrenic patients with excess of body mass caused by atypical antipsychoticsA sample included 61 patients, 53 men and 8 women, with ICD-10 episodic schizophrenia in the remission after treatment with atypical neuroleptics (risperidon, olanzapine, clozapine). All patients were featured by therapeutically caused excess of body mass (obesity of different degrees) that hampered the further treatment. In 31 cases (the main group) atypical neuroleptics were substituted for traditional drugs that exerted lesser influence on body mass. Haloperidol (mean dosage 4,1 mg daily) was administered to 17 patients and trifluoperazine (mean dosage 7,1 mg daily) to 14 patients. It was shown that the substitution of atypical neuroleptics for traditional neuroleptic drugs allowed to stop further body mass gain and even decreased it without significant influence on psychopathological symptoms and other side-effects in patients with excess of body mass.