Cutaneous melanoma as an aggressive oncological disease with early growth of metastasis. Acquaintance with promising targets for targeted therapy. Consideration of the features of blocking the process of metastasis. Analysis of antitumor agents.
Аннотация к работе
Induction of apoptosis in cutaneous melanoma cells by cationic peptides cutaneous melanoma metastasis Cutaneous melanoma (CM) is an aggressive oncological disease with early growth of metastasis. Disseminated MK is resistant to most chemotherapeutic agents with letality in ~ 30% of cases. Molecular-directed therapy allows to solve this problem. Chaperone proteins nucleolin / NCL and nucleophosmin / NPM, which form about 70% of the nucleolus volume, are considered as promising targets for targeted therapy. These proteins are overexpressed in tumor cells. It was first proposed to use cationic peptides - a possible ligands for receptor NCL - for the induction of apoptosis in cutaneous melanoma cell cultures. Metastatic cutaneous melanoma is one of the prevalent skin cancers which upon the progression has no specific prolonged treatment. Research of diagnostics biomarkers, as well as predictive and prognostic markers is the actual problem. Blockage of the metastasis process also remains a significant clinical cha